Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Τετάρτη, 16 Ιανουαρίου 2019

Τhe minimum fascia–tumor distance (MFTD) criterion is more feasible for benign tumors than for malignant tumors for the localization of parotid tumors. For benign parotid tumors, US is enough to guide operations.

The Diagnostic Performance of Ultrasonography and Computed Tomography in Differentiating Superficial from Deep Lobe Parotid Tumors
Ping‐Chia Cheng  Chih‐Ming Chang  Chun‐Chieh Huang  Wu‐Chia Lo  Tsung‐Wei Huang  Po‐Wen Cheng Li‐Jen Liao
First published: 12 January 2019 https://doi.org/10.1111/coa.13289
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13289
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Abstract
Objectives
To validate and compare ultrasound (US) versus computed tomography (CT) criteria in the localization of superficial/deep lobe tumors of the parotid gland.

Design and Setting
This was a retrospective study of diagnostic tests performed from January 2008 to June 2017.

Participants
We included adult patients who were referred for a neck ultrasonography examination due to parotid tumors, and who subsequently underwent parotid surgery.

Main outcome measures
We assessed the location of parotid tumors, comparing the minimum fascia–tumor distance (MFTD) criterion on an US with eight CT criteria. We analyzed receiver operating characteristic (ROC) curves of the MFTD for malignant, benign, and all parotid tumors, and compared the accuracy, sensitivity, and specificity of the optimal MFTD with those of CT anatomical criteria.

Results
A total of 166 parotid tumors were included. The mean (SD) MFTD in superficial lobe tumors was significantly shorter than that of deep lobe tumors (1.2 [0.7] vs 2.8 [1.9] mm, effect size: 1.84; 95% CI, 1.27 to 2.41). The areas under the ROC curve were 0.63 for malignant tumors and 0.88 for benign tumors. The optimal MFTD cut point was 2.4 mm for the 154 benign parotid tumors and the accuracy, sensitivity, and specificity were 90%, 80% and 91%, respectively. For the 136 benign parotid tumors that underwent CT examination, three criteria had an accuracy of over 90% (FNline, tMasseter and Conn's arc), but the sensitivities were all below 50%.

Conclusions
MFTD is more feasible for benign tumors than for malignant tumors for the localization of parotid tumors. For benign parotid tumors, US is enough to guide operations.

Removal of indigo carmine dye by electrocoagulation using magnesium anodes with polarity change

Abstract

The aim of this study was to evaluate the performance of high purity magnesium and the magnesium-aluminum-zinc alloy AZ31 as sacrificial anodes in an electrocoagulation process with polarity change for the treatment of synthetic indigo carmine solution. It was studied the effect of the main parameters such as temperature, anodic material, current density, initial dye concentration, and agitation speed on the diminishing of indigo carmine concentration and non-purgeable organic carbon. Also, image analysis was used in conjunction with zeta potential measurements to understand the mechanism of flocs formation. The best results were 80% and 96% removal for non-purgeable organic carbon and dye content respectively at room temperature, by using turbulent regime, initial dye concentration of 100 mg L−1 and 50 A m−2 as current density with AZ31 alloy as electrodes. Particularly, high purity magnesium reached 75% in non-purgeable organic carbon removal and 86% in dye removal at the conditions described above. Finally, an additional improvement of 43% in the diminishing of the organic carbon content was observed when polarity change was used, a phenomenon that was attributed to the distribution of the oxidation reaction between electrodes, avoiding the saturation of the surface with oxide and hydroxide layers. Major areas and major fractal dimension were obtained by using a polarity change.



http://bit.ly/2sDv3ql

The Tralokinumab Story: Nothing is ever simple

Publication date: Available online 16 January 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Andrea J. Apter



http://bit.ly/2Fv5hg7

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http://bit.ly/2RPWf2Z

Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry

Publication date: Available online 16 January 2019

Source: Clinical Immunology

Author(s): Min Sun Shin, Kristina Yim, Kevin Moon, Hong-Jai Park, Subhasis Mohanty, Joseph W. Kim, Ruth R. Montgomery, Albert C. Shaw, Smita Krishnaswamy, Insoo Kang

Abstract

We investigated the effect of aging on the multi-dimensional characteristics and heterogeneity of human peripheral CD8+ T cells defined by the expression of a set of molecules at the single cell level using the recently developed mass cytometry or Cytometry by Time-Of-Flight (CyTOF) and computational algorithms. CD8+ T cells of young and older adults had differential expression of molecules, especially those related to cell activation and migration, permitting the clustering of young and older adults through an unbiased approach. The changes in the expression of individual molecules were collectively reflected in the altered high-dimensional profiles of CD8+ T cells in older adults as visualized by the dimensionality reduction analysis tools principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE). A combination of PhenoGraph clustering and t-SNE analysis revealed heterogeneous subsets of CD8+ T cells that altered with aging. Furthermore, intermolecular quantitative relationships in CD8+ T cells appeared to change with age as determined by the computational algorithm conditional-Density Resampled Estimate of Mutual Information (DREMI). The results of our study showed that heterogeneity, multidimensional characteristics, and intermolecular quantitative relationships in human CD8+ T cells altered with age, distinctively clustering young and older adults through an unbiased approach.



http://bit.ly/2QTqL7A

Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

Background: Androgenetic alopecia (AGA) results from shortening of the anagen phase of the hair cycle and, subsequently, miniaturization of hair follicles. Alopecia areata (AA) is a disease of autoimmunity where T cells attack anagen hair follicles and shows multifactorial etiology. Dickkopf-1 (DKK-1) is a gene that is responsible for transformation of anagen to catagen, which suggests that it is involved in development of both diseases. Objectives: To evaluate the tissue levels of dickkopf-1 in male patients with AGA and AA in comparison with controls, in an attempt to know its role in the pathogenesis of both disorders. Methods: DKK-1 immunohistochemical expression was evaluated in lesional scalp biopsies taken from 20 male patients with AGA evaluated clinically by the modified Norwood–Hamilton score, 20 male patients with AA evaluated clinically by SALT score, and 20 healthy controls within the same age and sex of the studied patients. Results: A highly significant difference in DKK-1 expression between patients with AGA and healthy controls was found (P2

http://bit.ly/2stVFK0