Children Experiencing First-Time or Prolonged Febrile Seizure Are Prone to Stress Hyperglycemia

The risk factors and clinical implications of stress hyperglycemia in children with febrile seizure remain uncertain. Among 479 children with febrile seizure, the prevalence of the stress hyperglycemia (blood glucose concentration ≥ 150 mg/dL) was 10.0%. Stress hyperglycemia group included larger proportion of first-time febrile seizure, prolonged febrile seizure, and smaller proportion of short febrile seizure in comparison with the non–stress hyperglycemia group. Stress hyperglycemia group demonstrated a lower pH and higher lactate levels than the non–stress hyperglycemia group. Multivariate analysis revealed that first-time febrile seizure (aOR = 3.741, P = .004) and prolonged febrile seizure (aOR = 12.855, P < .001) were significant risk factors for stress hyperglycemia. The rate of early febrile seizure recurrence in the emergency department was not different between the groups. These findings suggest that children experiencing first-time or prolonged febrile seizure are prone to stress hyperglycemia, and this can be related to febrile seizure severity. However, stress hyperglycemia is not predictive of early febrile seizure recurrence in the emergency department.

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15 April News

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Planning digital artery perforators using color Doppler ultrasonography: a preliminary report

Publication date: Available online 8 February 2016
Source:Journal of Plastic, Reconstructive & Aesthetic Surgery
Author(s): Kosuke Shintani, Kiyohito Takamatsu, Takuya Uemura, Ema Onode, Mitsuhiro Okada, Kenichi Kazuki, Hiroaki Nakamura
Digital artery perforator (DAP) flaps have been applied for the coverage of finger soft tissue defects. While an advantage of this method is that there is no scarification of the digital arteries, it is difficult to identify the location of the perforators during intraoperative elevation of the DAP flap. In this study, anatomically reliable locations of DAPs were confirmed using color Doppler ultrasonography in healthy volunteers. A successful case using an adiposal-only DAP flap for the coverage of a released digital nerve using preoperative DAP mapping with color Doppler ultrasonography is also described. A total of 40 digital arteries in 20 fingers of the right hands of five healthy volunteers (mean age: 32.2 years old) were evaluated. The DAPs were identified using color flow imaging based on the beat of the digital artery in the short axial view. In total, 133 perforators were detected, 76 (an average of 3.8 per finger) arising from the radial digital artery and 57 (an average of 2.9 per finger) arising from ulnar digital artery. Sixty-three perforators (an average of 3.2 per finger) in the middle phalanges and 70 (an average of 3.5 per finger) in the proximal phalanges were found. Overall, an average of 1.7 perforators from each digital artery was detected in the proximal or middle phalanges. Moreover, at least one DAP per phalanx was reliably confirmed using color Doppler ultrasonography. Preoperative knowledge of DAP mapping could make elevating the DAP flap easier and safer.

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Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

Organic & biomolecular chemistry

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