Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia

alwin shared this article with you from Inoreader Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia Via Innate Immunity Innate Immun. 2022 Jan;28(1):37-48. doi: 10.1177/17534259211069104.ABSTRACTCircular RNA (circRNA) represents an important regulator in infantile pneumonia progression. To clarify the role of circ_0026579 in this disease, LPS was used to treat WI-38 cells to mimic inflammation injury. The levels of inflammatory factors were determined by ELISA assay. Cell proliferation and apoptosis were measured by MTT assay, EdU staining and flow cytometry. The protein levels of cyclinD1, cleaved-caspase-3 and insulin-like growth factor 2 (IGF2) were examined using Western blot analysis. Cell oxidative stress was assessed by detecting MDA level and SOD activity. The expression of circ_0026579, miR-24-3p and IGF2 were analyzed using quantitative real-time PCR, and the interaction between miR-24-3p and circ... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection

alwin shared this article with you from Inoreader A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection Via Innate Immunity Innate Immun. 2022 Feb 24:17534259221080543. doi: 10.1177/17534259221080543. Online ahead of print.ABSTRACTBactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is an innate immunity defense protein. Our previous studies proved its antibacterial and antiviral effects, but its role in fungi remains unknown. The study aimed to identify antifungal peptides (AFP) derived from BPIFA1, and three antimicrobial peptides (AMP1-3) were designed. The antifungal effects were proved by growth inhibition assay. AMP3 activity was confirmed by germ tube growth experiment and XTT assay. Its effects on cell wall and membrane of Candida albicans were assessed by tannic acid and Annexin V-FITC/PI double staining, respectively. Additionally, scanning electron microscope (SEM) and tra... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol

alwin shared this article with you from Inoreader Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol Via Journal of Oral and Maxillofacial Surgery Odontogenic infections are commonly encountered in OMS practices. Rarely, odontogenic infections can progress into craniocervical necrotizing fasciitis (CCNF). CCNF of the head and neck is a rare, potentially lethal disease process involving infection and subsequent destruction of fascial planes. Mortality ranges from 33% to 50% if the mediastinum is involved.1,2 CCNF diagnosis is based on clinical suspicion. Typical findings include dishwater-like purulence and easy spread of fascial planes using fingers.3 Treatment for CCNF usually consists of aggressive surgical debridement, source control, and intravenous antibiotics. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre

alwin shared this article with you from Inoreader Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre Via Journal of Oral and Maxillofacial Surgery There is a lack of consensus in the management of oral epithelial dysplasia (OED). The purpose of this study is: 1) to evaluate whether surgical excision with histologically negative margins impacts the 5-year malignant transformation rate of OED, and 2) to compare the disease-specific survival outcome of patients diagnosed with oral squamous cell carcinoma (OSCC) that progressed from OED to those presenting with OSCC on initial biopsy. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference?

alwin shared this article with you from Inoreader Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference? Via Journal of Oral and Maxillofacial Surgery Traumatic maxillofacial injuries requiring maxillomandibular fixation (MMF) traditionally necessitate airway management via tracheostomy or submental intubation. The aim of this study is to understand whether the retromolar space can accommodate passage of a reinforced endotracheal tube (ETT) without interfering with establishing MMF, a technique previously described as retromolar intubation. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mandible Fracture Patterns after Low Kinetic Energy Trauma Common in an Urban Level I Trauma Center

alwin shared this article with you from Inoreader Mandible Fracture Patterns after Low Kinetic Energy Trauma Common in an Urban Level I Trauma Center Via Journal of Oral and Maxillofacial Surgery Facial trauma and fractures are injuries that may require attention from emergency departments (ED). The Nationwide Emergency Department reported that in 2007 alone 407,167 ED visits included a facial fracture, with annual costs close to $1 billion.1 Of these, 1 of the most common injury sites of the maxillofacial region is the mandible.2 Despite previous studies having shown trends in etiology, epidemiology, and treatment outcomes, there is still no consensus on culture-, city-, and facility-specific variables by reporting trauma centers.3 For example, some studies mention motor vehicle accidents and interpersonal violence as leading causes of mandibular fractures, while other studies list falls, all with varying geographic influences as well. (Source: Journal of Oral and Maxillofacial Su... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Head and Neck Langerhans Cell Histiocytosis in Children

alwin shared this article with you from Inoreader Head and Neck Langerhans Cell Histiocytosis in Children Via Journal of Oral and Maxillofacial Surgery Langerhans Cell Histiocytosis (LCH) is a sporadic myeloid neoplasm with proliferation of dendritic cells.1 In the United States, LCH has an estimated annual incidence of approximately 1 per million children.2 Controversy exists regarding management of LCH in head and neck: debridement, chemotherapy, or both. Few reports describe LCH in the OMS literature. The purpose of this study was to present experience with LCH of head and neck in children.This was a retrospective review of children with LCH at Children's Healthcare of Atlanta from 2009 to 2020. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions?

alwin shared this article with you from Inoreader Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions? Via Journal of Oral and Maxillofacial Surgery It is unclear whether certain bacteria initiate the development of inflammatory jaw conditions, or whether these diseases create a milieu for dysbiosis and secondary colonization of indigenous flora. At present, there are no comparative studies on the types of bacteria that colonize different inflammatory jaw conditions. Accordingly, this study aims to identify and compare the types of bacteria isolated in osteomyelitis, osteoradionecrosis, and MRONJ. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis

alwin shared this article with you from Inoreader Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis Via Journal of Oral and Maxillofacial Surgery This study aimed to explore the applicability of resorbable-screw osteosynthesis in the treatment of SFMC. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Orbital fractures with concomitant ocular nerve palsy: An insidious and potentially misleading association in surgical decision-making.

alwin shared this article with you from Inoreader Orbital fractures with concomitant ocular nerve palsy: An insidious and potentially misleading association in surgical decision-making. Via Journal of Oral and Maxillofacial Surgery Orbital fractures (OFs) are common, but their association with concomitant traumatic ocular nerve palsy (TONP) is exceptional and may potentially cause confusing clinical pictures of oculomotor involvement. The purpose of the present study was to describe a series of patients with OFs and concomitant TONP following facial trauma and to evaluate clinical features, diagnostic pitfalls and final functional outcome. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction.

alwin shared this article with you from Inoreader Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction. Via Journal of Oral and Maxillofacial Surgery Virtual surgical planning (VSP), computer aided design/computer aided modeling (CAD/CAM), and three-dimensional (3D) printing technology have been shown to improve surgical accuracy and efficiency in head and neck reconstruction. However, persisting criticism of the technology is that it does not adequately address the soft-tissue related aspects of the reconstructive surgery. Prior publication on the computed tomographic angiography (CTA) perforator localization technique has demonstrated how soft tissue planning can be incorporated directly into existing VSP workflows. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.