Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro

• Expression of Cathepsin L and CD133 were correlated with human glioma malignancy.• Knockdown of Cathepsin L leads to radiosensitization in GSCs.• The improved radiosensitivity was through stemness, DNA repair, and apoptosis.• Knockdown of Cathepsin L exhibited less tumor growth after radiation in vivo.• Cathepsin L is a promising therapeutic target for clinical therapy in GBM patients.

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P8hW4g
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from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QO1h81
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