Evaluation of miRNA-expression and clinical tumour parameters in oral squamous cell carcinoma (OSCC)

Publication date: Available online 22 April 2016 Source:Journal of Cranio-Maxillofacial Surgery Author(s): J. Moratin, S. Hartmann, R. Brands, M. Brisam, G. Mutzbauer, C. Scholz, A. Seher, U. Müller-Richter, A.C. Kübler, C. Linz Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common malignancy worldwide. The past decades have not led to substantial improvement in diagnosis and therapy. Analysis of miRNA expression may help to determine the progression profiles and outcomes of many different diseases, including HNSCC. Therefore, in this investigation, 43 formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were micro-dissected, analysed for expression of 30 miRNAs and were compared with non-tumorous tissue. Furthermore, correl...

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