Osteitis fibrosa cystica of primary hyperparathyroidism

Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism: Description

A 28-year-old woman presented with bone pains and progressive proximal muscle weakness of 2 years duration. Examination revealed significant bony tenderness over the spine and both hips and severe proximal muscle weakness in the lower limbs. The rest of the examination was normal. Biochemical evaluation showed parathyroid hormone (PTH)-dependent hypercalcaemia (serum calcium 12.4 mg/dL (normal 8.4–10.2); PTH >1900 pg/mL (normal 8–50)). Remaining blood bone biochemistry was as follows: phosphorus 2 mg/dL (normal 2.5–4.5), alkaline phosphatase 1112 U/L (normal 40–125), creatinine 0.9 mg/dL (normal 0.6–1.2) and 25 hydroxy vitamin D 12.5 ng/mL (normal 30–75). A skeletal survey performed was diagnostic of osteitis fibrosa cystica with multiple cystic lesions secondary to brown tumours in the pelvis and femoral bones (figure 1A). A marked reduction in bone mineral density (BMD) was seen at all sites (figure 2). There was no evidence of renal stones. A technetium-sestamibi uptake scan revealed a lesion in the...

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ULV9RD
via IFTTT