Milk: An epigenetic inducer of FoxP3 expression

Milk: An epigenetic inducer of FoxP3 expression: Kirchner et al1 recently implicated microRNAs of unprocessed cow's milk in mediating the allergy-preventive effect of farm milk.2 On the basis of translational evidence, we predicted that the transmission of milk-derived immune-regulatory exosomal microRNAs including microRNA-148a, microRNA-155, microRNA-29b, and microRNA-21 prevent atopy by inducing FoxP3+ regulatory T (Treg)-cell differentiation.3 Notably, farm milk intake is associated with higher FOXP3 demethylation and higher Treg-cell numbers.

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