Non–IgE-mediated food allergy syndromes

In contrast to IgE-mediated food allergies, diagnosis of the various non–IgE-mediated food allergy syndromes can be challenging because of the overall lack of noninvasive confirmatory testing for these disorders. Many of the non–IgE-mediated food allergy syndromes are diagnosed clinically based on history and managed empirically with food avoidance. Therefore, it is essential for the practicing allergist to be familiar with the myriad presentations of non–IgE-mediated food allergy. This review focuses on the presentation and management of the non–IgE-mediated food allergy syndromes.

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