The clinical relevance of filaggrin mutations

Allergic diseases, including atopic dermatitis (AD), have increased in prevalence and now affect approximately 20% of the world population.1,2 AD (the most common form of eczema) is the most common chronic inflammatory skin disease in children and is characterized by dry, itchy skin and reduced skin barrier function.2,3 Children with AD often develop other allergic diseases, including asthma and food allergy.1 Within the first 7 years of life, approximately 70% of children with AD develop allergic rhinitis (AR) and asthma.

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