Cellular Responses to Replication Stress: Implications in Cancer Biology and Therapy

Publication date: Available online 22 November 2016
Source:DNA Repair
Author(s): Hui-Ju Hsieh, Guang Peng
DNA replication is essential for cell proliferation. Any obstacles during replication cause replication stress, which may lead to genomic instability and cancer formation. In this review, we summarize the physiological DNA replication process and the normal cellular response to replication stress. We also outline specialized therapies in clinical trials based on current knowledge and future perspectives in the field.



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