Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life

Publication date: 21 November 2016
Source:Developmental Cell, Volume 39, Issue 4
Author(s): Domenico F. Galati, Brian J. Mitchell, Chad G. Pearson
Centrioles acquire subdistal appendages (sDAPs) during primary cilium formation. In this issue of Developmental Cell, Mazo et al. (2016) demonstrate that sDAPs keep cilia submerged within deep membrane invaginations. When sDAPs and centrosome cohesion are disrupted, cilia surface to the plasma membrane, which may alter mechanical and chemical signal transduction.

Teaser

Centrioles acquire subdistal appendages (sDAPs) during primary cilium formation. In this issue of Developmental Cell, Mazo et al. (2016) demonstrate that sDAPs keep cilia submerged within deep membrane invaginations. When sDAPs and centrosome cohesion are disrupted, cilia surface to the plasma membrane, which may alter mechanical and chemical signal transduction.


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