Systemic Treatment of Brain Metastases

Publication date: February 2017
Source:Hematology/Oncology Clinics of North America, Volume 31, Issue 1
Author(s): Saiama N. Waqar, Daniel Morgensztern, Ramaswamy Govindan

Teaser

Lung cancer continues to be the leading cause of cancer-related mortality in the United States. Brain metastases are a significant problem in patients with lung cancer and have conventionally been treated with whole-brain radiation. This article reviews the data for systemic chemotherapy to treat brain metastasis from lung cancer and examines the activity of small molecule tyrosine kinase inhibitors for the targeted therapy for brain metastases from EGFR-mutant and ALK-rearranged non–small cell lung cancer. Future directions for evaluating the role of immunotherapy in treating brain metastasis are also discussed.


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