The expression of Smad signaling pathway in myocardium and potential therapeutic effects.

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The expression of Smad signaling pathway in myocardium and potential therapeutic effects.

Histol Histopathol. 2016 Nov 15;:11845

Authors: Duan Y, Zhu W, Liu M, Ashraf M, Xu M

Abstract
Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.

PMID: 27844469 [PubMed - as supplied by publisher]

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