A new hypnic paradigm of neurodegenerative proteinopathies

Sleep is a major emerging area of interest in neurodegenerative diseases. A compelling case has been made that sleep disruption contributes to the pathogenesis of Alzheimer's disease (AD)[1]. In this paper we draw attention to mounting recent evidence that disordered sleep is a feature of diverse neurodegenerative diseases besides AD, and may differentiate these diseases on clinical, electrophysiological and neurohormonal grounds[2-8]. In addition to well-recognised sleep phenotypes of Parkinson's and prion disease, clinical sleep disturbance and disordered sleep architecture are increasingly reported in the frontotemporal dementia (FTD) spectrum[2,3].

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