Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer with nearly 450,000 new cases reported annually [1]. Despite advances in cancer management, the overall survival rate of patients has not improved during the last 20years, with 5-year survival rates remaining at 45–50% [2]. The major reason for poor prognosis is the propensity of HNSCC to invade adjacent tissues. The rate of local recurrence at the primary site and regional recurrence at the peripheral lymph nodes is approximately 33–40% [2–4].

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