Can ratio of the biggest tumor diameter to total tumor diameter be a new parameter in the differential diagnosis of agressive and favorable multifocal papillary thyroid microcarcinoma?

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer accounting for approximately 85% of all thyroid malignancies [1]. Papillary thyroid microcarcinoma (PTMC) is defined as PTC equal to or less than 1cm and its incidence has increased by 40% in the last three decades. This increase was mainly attributed to the extensive use of thyroid ultrasonography (US) and US-guided fine-needle aspiration biopsy (FNAB), and more detailed histopathological examination of surgical specimens [2,3].

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