Immediate and residual effects of low-dose nandrolone decanoate and treadmill training on adipose and reproductive tissues of male Wistar rats.

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Immediate and residual effects of low-dose nandrolone decanoate and treadmill training on adipose and reproductive tissues of male Wistar rats.

Arch Physiol Biochem. 2016 Dec 25;:1-10

Authors: Rodrigues JM, Oliveira VP, P Furlan J, Munhoz AC, S Rempel MR, Brito MN, Brito NA, Pedrosa MM, M Costa CE

Abstract
CONTEXT: Residual effects after nandrolone decanoate (ND) treatment are not reported.
OBJECTIVE: Immediate and residual effects of low-dose ND and treadmill training were investigated.
MATERIALS AND METHODS: Male rats were trained and/or ND-treated for four weeks and the assessments were made after this period or four weeks later.
RESULTS: The groups did not differ in final plasma glucose or AUC of the ivGTT, but hyperinsulinemia was noticed in some trained/treated groups. Training with ND increased muscle mass and ND decreased the reproductive structures. Decreased fat with training was reversed by detraining.
DISCUSSION: The anabolic action of ND on skeletal muscle was enhanced by training. Fat and lipid changes were more linked to training/detraining, but the effects of ND on the reproductive structures persisted after treatment.
CONCLUSIONS: The effects of training on fat and muscle were not maintained after detraining, but low-dose ND had persistent effects on the reproductive structures.

PMID: 28019124 [PubMed - as supplied by publisher]

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