INSULIN RESISTANCE IS ASSOCIATED WITH SMALLER CORTICAL BONE SIZE IN NON-DIABETIC MEN AT THE AGE OF PEAK BONE MASS.

INSULIN RESISTANCE IS ASSOCIATED WITH SMALLER CORTICAL BONE SIZE IN NON-DIABETIC MEN AT THE AGE OF PEAK BONE MASS.

J Clin Endocrinol Metab. 2016 Dec 21;:jc20163609

Authors: Verroken C, Zmierczak HG, Goemaere S, Kaufman JM, Lapauw B

Abstract
CONTEXT: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be explained by insulin resistance affecting bone structure and/or material properties, few studies have investigated the association between insulin resistance and bone geometry.
OBJECTIVE: We aimed to explore this association in a cohort of non-diabetic men at the age of peak bone mass.
DESIGN, SETTING AND PARTICIPANTS: 996 non-diabetic men aged 25-45 years were recruited in a cross-sectional, population-based sibling-pair study at a university research center.
MAIN OUTCOME MEASURES: Insulin resistance evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR), with insulin and glucose measured from fasting serum samples. Bone geometry assessed using peripheral quantitative computed tomography at the distal radius and the radial and tibial shaft.
RESULTS: In age, height and weight-adjusted analyses, HOMA-IR was inversely associated with trabecular area at the distal radius and with cortical area, periosteal and endosteal circumference, and polar strength-strain index at the radial and tibial shafts (ß≤-0.13,p<0.001). These associations remained essentially unchanged after additional adjustment for dual energy X-ray absorptiometry-derived body composition, bone turnover markers, muscle size or function measurements, or adiponectin, leptin, IGF-1, or sex steroid levels.
CONCLUSION: In this cohort of non-diabetic men at the age of peak bone mass, insulin resistance is inversely associated with trabecular and cortical bone size. These associations persist after adjustment for body composition, muscle size or function, or sex steroid levels, suggesting an independent effect of insulin resistance on bone geometry.

PMID: 28001453 [PubMed - as supplied by publisher]

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