Manifestations of hereditary angioedema

Hereditary angioedema (HAE) is characterized by sudden edema of the larynx, lips, oropharynx, periorbital tissues, abdomen, or limbs.1 Episodes of severe headaches and visual disturbances are also commonly see in patients with HAE. Symptoms usually resolve within minutes to hours. Neurologic manifestations of HAE are more rare, but there have been case reports in the literature involving cerebral edema2,3 and strokelike episodes.4 Local cerebral edema has been implicated in transient ischemic attacks (TIAs); although the mechanism is not well delineated, rapid onset of edema might temporarily reduce blood flow in certain blood vessels, leading to TIA symptoms, which resolve as the edema resolves.

http://ift.tt/2hQeAbv