Neutrophils are a major source of the epithelial barrier disrupting cytokine Oncostatin M in mucosal airways disease

In this study, we show that neutrophils are a major source of OSM, the epithelial barrier disrupter, in chronic rhinosinusitis (CRS). GM-CSF, a known stimulus of OSM production, was also elevated in nasal polyps and was detected at levels sufficient to induce in vitro OSM production in peripheral blood neutrophils. OSM-producing neutrophils were found in tissues from patients with severe asthma. Neutrophils may be an important source of OSM resulting in impaired epithelial barrier function.

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