NSAIDs induced regulation of alternatively spliced transcript isoforms: possible role in cancer and Alzheimer disease.

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NSAIDs induced regulation of alternatively spliced transcript isoforms: possible role in cancer and Alzheimer disease.

Curr Cancer Drug Targets. 2016 Dec 15;

Authors: Husain MA, Ur Rehman S, Sarwar T, Ishqi HM, Tabish M

Abstract
Alternative splicing is one of the post transcriptional modifications through which multiple mRNA isoforms are produced from any gene, also known as splice variants. These are expressed in tissue and developmental stage specific manner that are important during the development. Most human genes undergo alternative splicing, thus contributing to the diversity of proteins. However, many abnormal splicing processes may result in human diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) are medications that act as analgesics, anti-pyretics and anti-inflammatory by affecting Cox genes and their products. Usually NSAIDs cause gastrotoxicity however, isozyme-specific NSAIDs exhibit a comparatively reduced gastrotoxic effect. Such NSAIDs have a broader range of application particularly as chemo-preventive drugs. It is known that changes at the active site of an enzyme may illicit a diverse range of responses. Such changes might explain the underlying reason as to why patients appear to respond differently to different NSAIDs. We have reviewed in detail the insight into the action of NSAIDs targeting specific isoforms of different genes. In future, the complete understanding of NSAIDs associated genes and their expression studies may be helpful in generating drugs with increased specificity.

PMID: 27993118 [PubMed - as supplied by publisher]

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