Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma

While mucinous adenocarcinomas occur more frequently in the colon, appendix, breast, lung and ovary, mucinous adenocarcinoma of the salivary gland (MAC) represents only 0.1% of all salivary gland tumors. MAC is a rare cancer: only 73 MAC cases have been registered in the U.S. from 1998 to 2012 [1–3]. The majority of salivary MAC present with cervical nodal metastases (63%) and primary treatment is surgical excision, nodal dissection, with or without post-operative radiation therapy. Despite this aggressive treatment regimen, 10-year survival is only 44% [3].

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