Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence

Despite all treatment efforts the incidence of recurrences in oral squamous cell carcinoma (OSCC) has not decreased considerably in the past two decades. The current rate of local and loco-regional recurrences is 10–30% in all OSCC patients, and the mean overall 5 year tumor-free survival rate does not exceed 50% [1]. This is partly due to the presence of (pre)malignant cells in the remaining tissue after resection, that may lead to the development of a new tumor in time. These relapses can be subdivided as follows, i.e.

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