Consolidative thoracic radiotherapy for extensive stage small cell lung cancer.

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Consolidative thoracic radiotherapy for extensive stage small cell lung cancer.

Oncotarget. 2017 Jan 19;:

Authors: Zhang X, Yu J, Zhu H, Meng X, Li M, Jiang L, Ding X, Sun X

Abstract
Extensive stage small cell lung cancer (ES-SCLC) represents approximately half of all diagnosed small cell lung cancer worldwide. It is notorious for a high risk of local recurrence although it's sensitive to chemotherapy. Nearly 90% of intrathoracic failures happen in the first year after diagnosis. The cornerstone of treatment for ES-SCLC is etoposide-platinum based chemotherapy. Consolidative radiotherapy to thorax has diminished the incidence of local relapse, therefore it should be offered to patients with excellent response to induction first-line chemotherapy. This review centers on the clinical evidence for the use of thoracic radiotherapy (TRT) and current modalities of TRT delivery, then tries to determine a feasible way to conduct TRT in a selective group of cases.

PMID: 28118612 [PubMed - as supplied by publisher]

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