Could daratumumab be used to treat severe allergy?

Publication date: Available online 19 January 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Mark A. Blankestijn, Niels W.C.J. van de Donk, Kate Sasser, André C. Knulst, Henny G. Otten
In the management of allergic diseases, targeting IgE using biologicals is a current research focus. This proof of concept shows that plasma cell depletion using daratumumab results in decreased total and allergen-specific IgE levels.



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