Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis

Head and neck cancer (HNC) is the sixth most common cancer worldwide and is often managed with radiotherapy, either as monotherapy or in association with chemotherapy and surgery [1]. When salivary glands are within the irradiated field, irreversible salivary glands damage occurs in 63–93% of the patients [2]. Salivary gland damage typically manifests as reduced saliva secretion, which in turn can translate into a subjective sensation of dry mouth (xerostomia), oral discomfort, altered taste, difficulty with speaking, swallowing, chewing, and increased risk of dental disease.

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