Investigating the role of the newly described OSCC amoeboid phenotype in metastasis and chemoresistance of oral cancer

Cellular plasticity, as seen in epithelial-to-mesenchymal transition (EMT), may be partly responsible for metastasis and therapeutic failure. In addition to the epithelial and mesenchymal cells, we describe another oral squamous cell carcinoma (OSCC) stem phenotype, seen thus far only in aggressive tumours such as melanomas and sarcomas. This is the amoeboid cell, whose distinct properties we describe in OSCC for the first time.

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