Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Omalizumab is a humanized anti-IgE antibody that has been recommended for the management of persistent asthma associated with high serum IgE levels.1 Several cases have been reported in the literature that suggest its association with eosinophilic granulomatosis with polyangiitis (EGPA), which was previously called Churg-Strauss syndrome (CSS). EGPA is a rare necrotizing systemic vasculitis of medium and small blood vessels characterized by asthma, eosinophilia, and eosinophilic or granulomatous tissue inflammation.

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