Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer

With more than 500,000 new cases diagnosed each year head and neck cancer is the sixth most common cancer worldwide with surgery as the primary curative treatment. An inadequate resection margin in oral squamous cell carcinoma (OSCC) surgery is an important negative prognostic indicator for loco-regional control, distant metastasis, and overall survival. Recent studies suggest that inadequate resection margins (defined as tumour-positive or with a negative margin of <5mm) in oral cancer surgery range up to 85%, when the complete resection margin is assessed [1].

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