Proliferative verrucous leukoplakia: diagnosis, management and current advances

Publication date: Available online 24 January 2017
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Diogo Lenzi Capella, Jussara Maria Gonçalves, Adelino Antônio Artur Abrantes, Liliane Janete Grando, Filipe Ivan Daniel
IntroductionProliferative verrucous leukoplakia (PVL) is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucous carcinoma transformations.MethodsTo analyze the studies about PVL and develop a concise update. A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with PVL was realized.Results and discussionThere are not enough studies about PVL in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate.ConclusionMore research about PVL is necessary to understand and treat this disease.



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