Satb1: Restraining PD1 and T Cell Exhaustion

Publication date: 17 January 2017
Source:Immunity, Volume 46, Issue 1
Author(s): Briana G. Nixon, Ming O. Li
Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.

Teaser

Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.


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