Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN or Lyell disease) are rare diseases that cause acute destruction of the epithelium of the skin and mucous membrane by a violent immune response. SJS, TEN, and SJS-TEN overlap are considered variants in a spectrum of disease severity. SJS involves epidermal detachment of less than 10% of total body surface area, TEN involves epidermal detachment of more than 30% of total body surface area, and SJS-TEN overlap involves epidermal detachment of 10% to 29% of total body surface area.

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