Epicutaneous sensitization to house dust mite allergen requires IRF4-dependent dermal dendritic cells

Our findings identify skin IRF4-dependent cDC2 and not Langerhans cells as crucial players in Th2 sensitization to HDM. How alterations in skin-expressed proteins or cytokines in patients at risk for developing asthma could interfere with this basic mechanism of DC-driven type 2 immunity will need to be addressed.

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