Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis.

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Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis.

Chin J Integr Med. 2016 Oct;22(10):795-800

Authors: Tao L, Wang S, Zhao Y, Wang AY, Zhang L, Ruan JS, Fan FT, Liu YP, Li Y, Yue ZQ, Qian WH, Chen WX, Lu Y

Abstract
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

PMID: 27358204 [PubMed - indexed for MEDLINE]

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