Re-irradiation for recurrent and second primary cancers of the head and neck

Despite advances in the multi-disciplinary management of head and neck cancer, a significant proportion of patients who present with locally advanced disease subsequently develop recurrences. Locoregional recurrences in previously irradiated fields have historically carried a poor prognosis with a median survival of 6months with best supportive care [1,2]. As locoregional recurrences after definitive radiation may indicate intrinsic tumor resistance, salvage surgery is the preferred treatment modality for patients whenever possible.

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