Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray

Because there is evidence for local production of IgE in the nasal mucosa,1-3 methods to measure allergen-specific IgE (sIgE) at nasal level in patients with allergic rhinitis (AR) are of great interest. Nasal secretions (NasSec) are easily collected with various noninvasive methods4 and are suitable for IgE measurements.5-7 Nevertheless, IgE "classic" assays, based on immunoenzymatic methods and allergen extracts, require large volumes and are inefficient in detecting the low amounts of IgE in NasSec.

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