Systemic Innate Immune Activation in Food Protein Induced Enterocolitis Syndrome (FPIES)

Using blood obtained before and after food challenges for FPIES, we show that individuals with symptoms in response to challenge have activation of neutrophils, monocytes, eosinophils, and NK cells that is not observed in those who have outgrown FPIES. This novel finding places the innate immune system at the center of FPIES pathogenesis.

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