Xanthomatous Meningioma: A Case Report.

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Xanthomatous Meningioma: A Case Report.

Turk Neurosurg. 2016 Dec 27;:

Authors: Ersoz S, Yilmaz ZS, Eyüboglu İ, Yazar U

Abstract
Meningioma is a neoplasm derived from meningothelial cells. Grade1 meningiomas consist 9 different subtypes. One of the rare subtypes is metaplastic meningioma. Metaplastic meningioma could be defined as ''xanthomatous meningioma'' in the presence of prevalent xanthomatous changes. A 32 years old male patient had admitted to outpatient clinics with complaints of vertigo and tinnitus. Magnetic resonance imaging revealed a large mass of 7.4 cm in the right frontal region with an extra axial localization. Resection material demonstrated a neoplasm composed of classic meningothelial meningioma areas accompanied with areas of xanthomatous changes, containing cells with clear, vacuolated cytoplasm. EMA, Vimentin, and progesterone expression were evident in both xanthomatous and meningothelial meningioma areas. Additionally, CD68 positivity was also observed in xanthomatous areas. EMA positivity is a neoplastic marker for xanthomatous cells and is a critic marker to differentiate these cells from macrophages which is crucial for pathologists in differential diagnosis. Xanthomatous meningiomas are quite rare and our case presentation is the 7th one in the current literature.

PMID: 28191624 [PubMed - as supplied by publisher]

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