Fluorescent Multi-Responsive Cross-linked P(N-isopropylacrylamide)-Based Nanocomposites for Cisplatin Delivery.

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Fluorescent Multi-Responsive Cross-linked P(N-isopropylacrylamide)-Based Nanocomposites for Cisplatin Delivery.

Drug Dev Ind Pharm. 2017 Mar 30;:1-18

Authors: Shakoori Z, Ghanbari H, Omidi Y, Pashaiasl M, Akbarzadeh A, Jomeh Farsangi Z, Mahdi Rezayat S, Davaran S

Abstract
Magnetic, pH and temperature-sensitive, poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposite with fluorescent properties, were synthesized by free radical copolymerization-cross linking of NIPAM, N, N-dimethylaminoethyl methacrylate (DMAEMA) and 4-acrylamidofluorescein (AFA). The model anti-cancer drug, cisplatin (CDDP), was loaded into the resulted nanogel. For the production of CDDP-loaded nanocomposite, Fe3O4 magnetic nanoparticles (MNPs) and CDDP were loaded into the nanogel. Field-emission scanning electron microscopy (FE-SEM) indicated that the size of nanogel and CDDP-loaded nanocomposite were about 90 and 160 nm, respectively. The encapsulation efficiency of CCDP was found up to % 65. The loaded CCDP showed sustained thermal and pH-responsive drug release. A high level of drug release was observed under the conditions of low pH and high temperature. The lower critical solution temperature (LCST) of synthesized nanogel was about 40˚ C. CDDP-loaded nanocomposite showed a volume phase transition from 282 to 128 nm at its LCST. Accordingly, in the present study, the synthesized nanocomposite can be employed as a stimuli-responsive anti-cancer drug delivery system and the pH and temperature of solution have the potential to monitor the drug release.

PMID: 28358256 [PubMed - as supplied by publisher]

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