High stromal Foxp3-positive T cell number combined to tumor stage improved prognosis in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and males are more often diagnosed for HNSCC than females with a ratio ranging from 2:1 to 4:1 [1]. Beside tobacco and alcohol consumption, HPV infection appears as a new risk factor of this cancer but with contradictory prognostic values. The discrepancy between studies could be explained as the prevalence for HPV infection in oropharyngeal cancer is nearby 70% in North America whereas it is around 40% in Europe [2,3].

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