Idiopathic avascular necrosis associated with humoral deficiency

The prevalence of avascular necrosis (AVN) of the femoral head is unknown, but estimates indicate that the incidence is between 10,000 and 20,000 new cases a year, with a smaller fraction of those being idiopathic.1 Idiopathic AVN has been associated with a variety of autoimmune conditions, including systemic lupus erythematosus and antiphospholipid syndrome.2 It has also been associated with infections and immunodeficiencies, such as human immunodeficiency virus (HIV).3 It has never been described in association with a functional humoral deficiency.

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