IgE and antiviral immune response in asthma

We read with interest the article by Kantor et al,1 in which they showed that rhinovirus-triggered asthma exacerbation was associated with higher asthma exacerbation severity and drove a higher antigen-specific IgE response. Looking specifically at mouse and dust mite sensitization, they found that the magnitude of the rise in specific IgE level was associated with the severity of the rhinovirus-triggered asthma exacerbation. On the basis of this, they concluded that interactions between rhinovirus infection and allergen-specific IgE levels may help to explain interindividual variation in disease manifestation.

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