N-Pyrrylarylsulfones with High Therapeutic Potential.

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N-Pyrrylarylsulfones with High Therapeutic Potential.

Molecules. 2017 Mar 09;22(3):

Authors: Famiglini V, Castellano S, Silvestri R

Abstract
This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.

PMID: 28282943 [PubMed - in process]

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