[Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans].

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[Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans].

Pan Afr Med J. 2016;25:205

Authors: Safini F, Bouchbika Z, Bennani Z, Belkheiri S, Attar HE, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A

Abstract
Primitive large cell neuroendocrine tumor of the breast is an extremely rare entity. Less than ten cases have been reported in the literature. We report a new case of a 61-year old male patient presenting with locally advanced tumor of the right breast, immediately metastasized to the lungs and pleura, staged cT4bN1M1. The patient received eight cycles of Docetaxel-based chemotherapy every 21 days, with a good clinical and radiological response (>50%), followed by adjuvant tamoxifen with disease stabilization for 18 months. Immunohistochemistry is still essential to determine the neuroendocrine nature of this tumor. Treatment is not well codified due to the rarity of this type of cancer.

PMID: 28292162 [PubMed - indexed for MEDLINE]

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