Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) expression in brain arteriovenous malformations (bAVM) and its association with bAVM size.

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Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) expression in brain arteriovenous malformations (bAVM) and its association with bAVM size.

World Neurosurg. 2017 Mar 06;:

Authors: Neyazi B, Tanrikulu L, Wilkens L, Hartmann C, Stein KP, Dumitru CA, Sandalcioglu IE

Abstract
BACKGROUND: and Purpose: Brain arteriovenous malformations (bAVM) are severe conditions which can cause severe neurological deficits and mortality. The underlying cellular and molecular mechanisms associated with bAVM growth and rupture still remain unclear. The objective of this study was to explore the potential role of PLOD2 (Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) in the pathophysiology of bAVM.
METHODS: Expression and localization of PLOD2 were analyzed on tissue microarrays from bAVM patients (n=60) by immunohistochemistry. Correlations between PLOD2 levels and clinical parameters were examined with Pearson's test or Spearman's rank correlation coefficient. Comparison between different clinical parameters was performed using t-test or non-parametric Mann-Whitney U-test. Fisher's exact test was used for categorical data.
RESULTS: PLOD2 was mainly expressed within the tunica media of the blood vessels. High levels of PLOD2 expression correlated with bAVM size (linear regression: p=0.0083, R(2)=0.158). Small bAVM showed a higher frequency of hemorrhage compared to large ones (p=0.001). Although PLOD2 was not directly associated with bAVM hemorrhage, high PLOD2-expressing bAVM had a lower frequency of hemorrhage compared to low or medium PLOD2-expressing bAVM (25% vs. 63% and 75%, respectively).
CONCLUSIONS: This study reports for the first time the expression of PLOD2 in bAVM and suggests a potential role of PLOD2 in bAVM pathophysiology. These findings contribute to an better understanding of the microenvironment of bAVM and may foster the development of improved therapeutic strategies for this disease.

PMID: 28279775 [PubMed - as supplied by publisher]

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