Protective effect of an astaxanthin nanoemulsion against neomycin-induced hair-cell damage in zebrafish

Degeneration of the mechanosensory hair cells of the inner ear sensory epithelia is the main cause of deafness. Hair cells are commonly lost through drug-and noise-induced trauma, as well as aging. Many recent studies have reported that the cause of damage to these hair cells is oxidative stress due to free radicals. In particular, hair cells are very susceptible to aminoglycosides [1]. Antioxidants reduce the generation of oxygen-derived free radicals, and various antioxidants have been marketed, with different dosage forms available for each agent.

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