The impact of time to treatment initiation on survival from head and neck cancer in north-eastern Italy

Fast staging procedures and treatment are crucial for the prognosis of head and neck squamous cell carcinomas (HNSCC). HNSCC have shown rapid tumor growth, with a doubling of tumor volume in approximately 90 days [1], resulting in poor outcomes in patients with delayed treatment initiation [2–4]. In the last decades, however, time to treatment initiation (TTI) has increased in several countries [5–8], as a consequence of rising use of high-definition diagnostic techniques and treatment personalization [4].

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