The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro.

Related Articles

The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro.

Immunopharmacol Immunotoxicol. 2017 Mar 14;:1-7

Authors: Guan S, Huang Y, Feng Z, Xu L, Jin Y, Lu J

Abstract
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon contaminant that is widely present in environmental sources, including food. This study aims to clarify the effects of B[a]P toxicity on activated mouse T cells in vitro. Our results show that B[a]P markedly inhibited Concanavalin A (ConA)-induced T lymphocyte proliferation and suppressed the production of the cytokines Interferon (IFN)-γ, Interleukin (IL)-2 and IL-4. Western blot and protein-DNA interaction assays were used to study how B[a]P affects signal transduction. The results revealed that B[a]P suppressed the ConA-induced activation of the Ca(2+)/CaM/NFκB and Ca(2+)/CaM/CaN/NFAT signal transduction pathways. These observations indicate that B[a]P has toxic effects on activated mouse T cells in vitro.

PMID: 28290727 [PubMed - as supplied by publisher]

http://ift.tt/2nJtBy3