Overwhelming evidence has demonstrated that human papillomavirus (HPV) plays a causal role in some oropharyngeal squamous cell carcinomas (OSCC) [1], in addition to cervical, anal, penile, vulva and vaginal cancers [2]. In the US, HPV is detected in two-thirds of oropharyngeal cancers [3]. Studies have shown HPV-OSCC is prevalent worldwide and incidence rates are expected to rise [4], with numbers in the US predicted to exceed cervical cancer cases by 2020 if the current trend continues [5]. Research has shown both oral sex and open mouth kissing are associated with acquisition of oral HPV infection [6].
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