Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene

A malignant odontogenic tumor (MOT) is a rare tumor that comprises up to 2.1% of all odontogenic tumors [1]. Among them, clear cell odontogenic carcinoma (CCOC) is quite a rare MOT. To date, 81 cases have been reported in the literature [2–14]. Histologically, CCOC commonly shows a biphasic tumor pattern consisting of large sheets of clear epithelial cells and irregular cords of basaloid cells with scant eosinophilic cytoplasm, supported by a fibrous stroma [15]. As clear cell areas are frequently seen in other oral neoplasms, it is important to rule out these neoplasms of the oral and maxillofacial regions to obtain a correct diagnosis.

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